Exploring the performance-controlling tablet disintegration mechanisms for direct compression formulations

The design and manufacture of tablets is a challenging process due to the complex interrelationships between raw material properties, manufacturing settings tablet properties. An important factor in formulation fact that properties drive disintegration dissolution performance final drug product. This study aimed identify mechanisms which control for 16 different immediate-release placebo formulations based on Each consisted two fillers (47% each), one disintegrant lubricant. Tablets were manufactured by direct compression using four combinations microcrystalline cellulose (MCC), mannitol, lactose dibasic calcium phosphate anhydrous (DCPA). mechanism was primarily driven filler combination, where MCC/lactose identified as wettability controlled, MCC/mannitol controlled DCPA-based (MCC/DCPA lactose/DCPA) swelling controlled. A change 2% porosity (MCC/lactose) caused significant acceleration (77% reduction time), whereas (MCC/DCPA) same did not considerably impact (3% time). By classifying these formulations, critical can be allow optimised.